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About Puck Ohi Lab

Welcome to the Ohi lab!

We are broadly interested in how cells build complex cytoskeletal networks using microtubules. Microtubules are dynamic polymers of tubulin, and are essential for many physiological processes, including the establishment of cell polarity, intracellular trafficking and cell division. Microtubules are organized in three-dimensional space by proteins that regulate microtubule dynamics, and also by molecular motors that use energy derived from ATP hydrolysis to reposition microtubules. Microtubule function is further extended through post-translational modifications that alter the ability of microtubule-binding proteins to recognize and act on them. We use biochemical and cell-based approaches to address central problems in microtubule cell biology, with a focus on mitosis, kinesins, and microtubule post-translational modifications.